Drug interactions
Clemastine + Clobazam
Severity: Moderate
Clemastine and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine, and a sedating antihistamine increases drowsiness, impaired coordination and the risk of respiratory depression. The effect is most important in older patients and those with respiratory disease.
What this interaction means in plain words
Clemastine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression from benzodiazepine GABA-A potentiation and central H1 receptor blockade.
What to do
Monitor for oversedation and falls, and consider a non-sedating antihistamine. Advise avoiding alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clemastine with Clobazam?
MediHelp rates the interaction as moderate. Clemastine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine, and a sedating antihistamine increases drowsiness, impaired coordination and the risk of respiratory depression. The effect is most important in older patients and those with respiratory disease.
How serious is the interaction between Clemastine and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, and consider a non-sedating antihistamine. Advise avoiding alcohol and driving until the response is known.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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