Drug interactions
Clemastine + Clorazepate
Severity: Moderate
Clemastine and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine and may substantially add to the drowsiness and psychomotor impairment caused by clorazepate. Older adults are particularly vulnerable to confusion and falls.
What this interaction means in plain words
Clemastine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS depression from central H1 antagonism and benzodiazepine GABA-A potentiation.
What to do
Consider a non-sedating antihistamine instead. If both are needed, counsel about driving and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Clorazepate?
MediHelp rates the interaction as moderate. Clemastine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating first-generation antihistamine and may substantially add to the drowsiness and psychomotor impairment caused by clorazepate. Older adults are particularly vulnerable to confusion and falls.
How serious is the interaction between Clemastine and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-sedating antihistamine instead. If both are needed, counsel about driving and monitor for oversedation.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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