Drug interactions
Clemastine + Difelikefalin
Severity: Moderate
Clemastine and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin is a kappa opioid receptor agonist that can cause dizziness, somnolence and mental status changes. A sedating antihistamine may add to these effects and impair alertness.
What this interaction means in plain words
Clemastine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depression from kappa opioid agonism and central H1 receptor blockade.
What to do
Monitor for excessive sedation, dizziness and falls, particularly in dialysis patients. Consider a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Clemastine with Difelikefalin?
MediHelp rates the interaction as moderate. Clemastine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin is a kappa opioid receptor agonist that can cause dizziness, somnolence and mental status changes. A sedating antihistamine may add to these effects and impair alertness.
How serious is the interaction between Clemastine and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and falls, particularly in dialysis patients. Consider a non-sedating antihistamine if one is needed.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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