Drug interactions
Clemastine + Etomidate
Severity: Moderate
Clemastine and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic induction agent, and clemastine adds sedative effects. Preoperative or concurrent sedating antihistamine use may increase postoperative drowsiness or deepen sedation.
What this interaction means in plain words
Clemastine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Etomidate belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Inform the anesthesia team of recent clemastine use and titrate sedation and monitor recovery. Avoid additional sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Clemastine with Etomidate?
MediHelp rates the interaction as moderate. Clemastine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic induction agent, and clemastine adds sedative effects. Preoperative or concurrent sedating antihistamine use may increase postoperative drowsiness or deepen sedation.
How serious is the interaction between Clemastine and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent clemastine use and titrate sedation and monitor recovery. Avoid additional sedatives where possible.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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