Drug interactions
Clemastine + Flibanserin
Severity: Moderate
Clemastine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating antihistamine that adds to flibanserin-induced drowsiness, dizziness and hypotension. It may also have a minor effect on CYP-mediated clearance, though this is not well established.
What this interaction means in plain words
Clemastine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depression; possible minor metabolic inhibition.
What to do
Monitor for excessive sedation and falls. Prefer a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Flibanserin?
MediHelp rates the interaction as moderate. Clemastine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating antihistamine that adds to flibanserin-induced drowsiness, dizziness and hypotension. It may also have a minor effect on CYP-mediated clearance, though this is not well established.
How serious is the interaction between Clemastine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and falls. Prefer a non-sedating antihistamine if one is needed.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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