Drug interactions
Clemastine + Hydromorphone
Severity: Moderate
Clemastine and Hydromorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine, and together with hydromorphone it increases drowsiness and psychomotor impairment. Older patients are especially vulnerable to confusion and falls.
What this interaction means in plain words
Clemastine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Hydromorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid and sedating antihistamine effects.
What to do
Monitor sedation and counsel on avoiding driving; consider a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Hydromorphone?
MediHelp rates the interaction as moderate. Clemastine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating first-generation antihistamine, and together with hydromorphone it increases drowsiness and psychomotor impairment. Older patients are especially vulnerable to confusion and falls.
How serious is the interaction between Clemastine and Hydromorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and counsel on avoiding driving; consider a non-sedating antihistamine as an alternative.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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