Drug interactions
Clemastine + Ivacaftor
Severity: Minor
Clemastine and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine has been listed as a weak CYP3A inhibitor, which could modestly raise ivacaftor exposure. The effect is expected to be small, and ivacaftor has a wide margin of safety at usual doses.
What this interaction means in plain words
Clemastine and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clemastine belongs to Respiratory; Ivacaftor belongs to Miscellaneous.
Why it happens
Possible weak inhibition of CYP3A-mediated ivacaftor metabolism, predicted rather than well documented.
What to do
No dose change is normally needed; monitor for ivacaftor adverse effects such as headache, dizziness or raised liver enzymes if combined long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clemastine and Ivacaftor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clemastine
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Clemastine with Ivacaftor?
MediHelp rates the interaction as minor. Clemastine and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clemastine has been listed as a weak CYP3A inhibitor, which could modestly raise ivacaftor exposure. The effect is expected to be small, and ivacaftor has a wide margin of safety at usual doses.
How serious is the interaction between Clemastine and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor for ivacaftor adverse effects such as headache, dizziness or raised liver enzymes if combined long term.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
