Drug interactions
Clemastine + Lasmiditan
Severity: Moderate
Clemastine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause drowsiness and dizziness, and their combined use may increase sedation and impair psychomotor performance. Lasmiditan labeling already warns about driving impairment and about additive effects with other CNS depressants.
What this interaction means in plain words
Clemastine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects from lasmiditan and the sedating H1 antihistamine clemastine.
What to do
Counsel patients not to drive or operate machinery for at least 8 hours after lasmiditan and to avoid additional sedatives where possible. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Clemastine with Lasmiditan?
MediHelp rates the interaction as moderate. Clemastine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause drowsiness and dizziness, and their combined use may increase sedation and impair psychomotor performance. Lasmiditan labeling already warns about driving impairment and about additive effects with other CNS depressants.
How serious is the interaction between Clemastine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive or operate machinery for at least 8 hours after lasmiditan and to avoid additional sedatives where possible. Consider a non-sedating antihistamine.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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