Drug interactions
Clemastine + Lomitapide
Severity: Moderate
Clemastine and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate, and inhibitors raise its exposure and the risk of hepatotoxicity and gastrointestinal effects. Clemastine is at most a weak CYP3A inhibitor, so the effect is likely small.
What this interaction means in plain words
Clemastine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Lomitapide belongs to Cardiovascular.
Why it happens
Possible weak inhibition of CYP3A4-mediated lomitapide metabolism.
What to do
Monitor liver enzymes and gastrointestinal tolerability, and keep the lomitapide dose within labeled limits for weak CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Clemastine with Lomitapide?
MediHelp rates the interaction as moderate. Clemastine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a sensitive CYP3A4 substrate, and inhibitors raise its exposure and the risk of hepatotoxicity and gastrointestinal effects. Clemastine is at most a weak CYP3A inhibitor, so the effect is likely small.
How serious is the interaction between Clemastine and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability, and keep the lomitapide dose within labeled limits for weak CYP3A4 inhibitors.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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