Drug interactions
Clemastine + Nabilone
Severity: Moderate
Clemastine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine with anticholinergic activity, and nabilone causes drowsiness and tachycardia. The combination may increase sedation and impair psychomotor performance.
What this interaction means in plain words
Clemastine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Monitor for excessive sedation or consider a non-sedating antihistamine. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Nabilone?
MediHelp rates the interaction as moderate. Clemastine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating first-generation antihistamine with anticholinergic activity, and nabilone causes drowsiness and tachycardia. The combination may increase sedation and impair psychomotor performance.
How serious is the interaction between Clemastine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation or consider a non-sedating antihistamine. Advise patients to avoid driving and alcohol.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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