Drug interactions
Clemastine + Paliperidone
Severity: Moderate
Clemastine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine with anticholinergic activity, and paliperidone also causes somnolence. Together they can produce excessive drowsiness, impaired psychomotor performance and additive anticholinergic effects, especially in older adults.
What this interaction means in plain words
Clemastine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and anticholinergic effects through H1 and muscarinic receptor blockade plus antipsychotic activity.
What to do
Monitor for oversedation, confusion and anticholinergic effects, and warn patients against driving. Consider a non-sedating antihistamine if an antihistamine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Paliperidone?
MediHelp rates the interaction as moderate. Clemastine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating first-generation antihistamine with anticholinergic activity, and paliperidone also causes somnolence. Together they can produce excessive drowsiness, impaired psychomotor performance and additive anticholinergic effects, especially in older adults.
How serious is the interaction between Clemastine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion and anticholinergic effects, and warn patients against driving. Consider a non-sedating antihistamine if an antihistamine is needed.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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