Drug interactions
Clemastine + Temazepam
Severity: Moderate
Clemastine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedating antihistamine combined with a benzodiazepine increases drowsiness and impairs psychomotor performance and next-day alertness. Falls and accidents are a particular concern in older patients.
What this interaction means in plain words
Clemastine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Avoid driving and alcohol; consider a non-sedating antihistamine or a lower temazepam dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Clemastine with Temazepam?
MediHelp rates the interaction as moderate. Clemastine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A sedating antihistamine combined with a benzodiazepine increases drowsiness and impairs psychomotor performance and next-day alertness. Falls and accidents are a particular concern in older patients.
How serious is the interaction between Clemastine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving and alcohol; consider a non-sedating antihistamine or a lower temazepam dose.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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