Drug interactions
Clemastine + Ziconotide
Severity: Moderate
Clemastine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide commonly causes dizziness, confusion and sedation, and a sedating antihistamine such as clemastine can add to these effects. Heightened cognitive impairment may be important given ziconotide's psychiatric and neurologic warnings.
What this interaction means in plain words
Clemastine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; ziconotide blocks N-type calcium channels while clemastine blocks H1 receptors.
What to do
Monitor for worsening sedation, confusion or mood change, and reduce or stop the antihistamine if cognitive effects emerge. Prefer a non-sedating antihistamine when an antihistamine is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Clemastine with Ziconotide?
MediHelp rates the interaction as moderate. Clemastine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide commonly causes dizziness, confusion and sedation, and a sedating antihistamine such as clemastine can add to these effects. Heightened cognitive impairment may be important given ziconotide's psychiatric and neurologic warnings.
How serious is the interaction between Clemastine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening sedation, confusion or mood change, and reduce or stop the antihistamine if cognitive effects emerge. Prefer a non-sedating antihistamine when an antihistamine is required.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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