Drug interactions
Clevidipine + Diltiazem
Severity: Moderate
Clevidipine and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block L-type calcium channels, so combining them can cause additive vasodilation and hypotension. Diltiazem also adds negative inotropic and chronotropic effects.
What this interaction means in plain words
Clevidipine and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Diltiazem belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic calcium channel blockade in vascular smooth muscle and the myocardium.
What to do
Monitor blood pressure and heart rate continuously during clevidipine infusion and titrate cautiously. Avoid the combination in patients with significant bradycardia or heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Diltiazem?
MediHelp rates the interaction as moderate. Clevidipine and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block L-type calcium channels, so combining them can cause additive vasodilation and hypotension. Diltiazem also adds negative inotropic and chronotropic effects.
How serious is the interaction between Clevidipine and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during clevidipine infusion and titrate cautiously. Avoid the combination in patients with significant bradycardia or heart failure.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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