Drug interactions
Clevidipine + Doxazosin
Severity: Moderate
Clevidipine and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure by different mechanisms, so combined use can cause additive hypotension. Clevidipine is an intravenous, rapidly titratable agent, so the effect is easy to observe and manage in monitored settings.
What this interaction means in plain words
Clevidipine and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Doxazosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 adrenergic blockade and L-type calcium channel blockade.
What to do
Titrate clevidipine to blood pressure targets with continuous monitoring. Watch for orthostatic symptoms after transition to oral therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Doxazosin?
MediHelp rates the interaction as moderate. Clevidipine and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure by different mechanisms, so combined use can cause additive hypotension. Clevidipine is an intravenous, rapidly titratable agent, so the effect is easy to observe and manage in monitored settings.
How serious is the interaction between Clevidipine and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine to blood pressure targets with continuous monitoring. Watch for orthostatic symptoms after transition to oral therapy.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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