Drug interactions
Clevidipine + Prazosin
Severity: Moderate
Clevidipine and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure through different mechanisms, so combined use can cause excessive hypotension, dizziness or syncope. Clevidipine is given intravenously with rapid titration, so effects appear quickly.
What this interaction means in plain words
Clevidipine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 blockade plus calcium channel blockade.
What to do
Monitor blood pressure closely during clevidipine titration. Reduce the dose of either drug if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Prazosin?
MediHelp rates the interaction as moderate. Clevidipine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure through different mechanisms, so combined use can cause excessive hypotension, dizziness or syncope. Clevidipine is given intravenously with rapid titration, so effects appear quickly.
How serious is the interaction between Clevidipine and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during clevidipine titration. Reduce the dose of either drug if hypotension occurs.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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