Drug interactions
Clevidipine + Sodium nitroprusside
Severity: Moderate
Clevidipine and Sodium nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are potent intravenous antihypertensives. Combined use can lead to excessive or abrupt drops in blood pressure.
What this interaction means in plain words
Clevidipine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Sodium nitroprusside belongs to Cardiovascular.
Why it happens
Additive arterial vasodilation via nitric oxide donation and L-type calcium channel blockade.
What to do
Use continuous arterial or close blood pressure monitoring and titrate infusion rates carefully. Reduce the dose of one agent when transitioning or combining.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sodium nitroprusside
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Sodium nitroprusside?
MediHelp rates the interaction as moderate. Clevidipine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are potent intravenous antihypertensives. Combined use can lead to excessive or abrupt drops in blood pressure.
How serious is the interaction between Clevidipine and Sodium nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use continuous arterial or close blood pressure monitoring and titrate infusion rates carefully. Reduce the dose of one agent when transitioning or combining.
What other medicines interact with Sodium nitroprusside?
MediHelp also lists interactions of Sodium nitroprusside with, for example, Avanafil, Nitric oxide, Sildenafil. The full list is on the Sodium nitroprusside page.
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