Drug interactions
Clobazam + Clonidine
Severity: Moderate
Clobazam and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam and clonidine are both sedating, and clonidine can lower blood pressure. Combining them may increase drowsiness, dizziness and psychomotor impairment.
What this interaction means in plain words
Clobazam and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Clonidine belongs to Cardiovascular.
Why it happens
Additive CNS depression through GABA-A potentiation and central alpha-2 agonism.
What to do
Monitor sedation and blood pressure, and use the lowest effective doses. Counsel patients to avoid alcohol and other depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Clonidine?
MediHelp rates the interaction as moderate. Clobazam and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam and clonidine are both sedating, and clonidine can lower blood pressure. Combining them may increase drowsiness, dizziness and psychomotor impairment.
How serious is the interaction between Clobazam and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and use the lowest effective doses. Counsel patients to avoid alcohol and other depressants.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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