Drug interactions
Clobazam + Ethinyl estradiol-levonorgestrel
Severity: Moderate
Clobazam and Ethinyl estradiol-levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP3A4 inducer and may reduce hormonal contraceptive concentrations. This could lower contraceptive efficacy and lead to breakthrough bleeding or unintended pregnancy.
What this interaction means in plain words
Clobazam and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
Why it happens
Induction of CYP3A4 by clobazam increases metabolism of ethinyl estradiol and levonorgestrel.
What to do
Recommend an additional non-hormonal contraceptive method during therapy and for about 28 days after clobazam is stopped. Consider an alternative contraceptive method such as an IUD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Clobazam and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak CYP3A4 inducer and may reduce hormonal contraceptive concentrations. This could lower contraceptive efficacy and lead to breakthrough bleeding or unintended pregnancy.
How serious is the interaction between Clobazam and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an additional non-hormonal contraceptive method during therapy and for about 28 days after clobazam is stopped. Consider an alternative contraceptive method such as an IUD.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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