Drug interactions
Clobazam + Ethinyl estradiol-norgestimate
Severity: Moderate
Clobazam and Ethinyl estradiol-norgestimate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak inducer of CYP3A4 and may modestly lower exposure to the estrogen and progestin in combined oral contraceptives. This could reduce contraceptive reliability, so the risk of breakthrough bleeding or unintended pregnancy may rise.
What this interaction means in plain words
Clobazam and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
Weak induction of CYP3A4 by clobazam increases the metabolism of ethinyl estradiol and norgestimate.
What to do
Advise an additional non-hormonal contraceptive method during clobazam therapy and for a short period after stopping it. Consider a method not dependent on hepatic metabolism if reliable contraception is essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as moderate. Clobazam and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak inducer of CYP3A4 and may modestly lower exposure to the estrogen and progestin in combined oral contraceptives. This could reduce contraceptive reliability, so the risk of breakthrough bleeding or unintended pregnancy may rise.
How serious is the interaction between Clobazam and Ethinyl estradiol-norgestimate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during clobazam therapy and for a short period after stopping it. Consider a method not dependent on hepatic metabolism if reliable contraception is essential.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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