Drug interactions
Clobazam + Isoniazid
Severity: Moderate
Clobazam and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP2C19, which converts the active metabolite N-desmethylclobazam to inactive forms. Levels of this metabolite can rise, increasing sedation, dizziness, and ataxia.
What this interaction means in plain words
Clobazam and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Inhibition of CYP2C19 by isoniazid reduces clearance of N-desmethylclobazam.
What to do
Monitor for sedation and ataxia, and reduce the clobazam dose if these occur. Review seizure control and adjust when isoniazid is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clobazam and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Isoniazid?
MediHelp rates the interaction as moderate. Clobazam and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid inhibits CYP2C19, which converts the active metabolite N-desmethylclobazam to inactive forms. Levels of this metabolite can rise, increasing sedation, dizziness, and ataxia.
How serious is the interaction between Clobazam and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and ataxia, and reduce the clobazam dose if these occur. Review seizure control and adjust when isoniazid is started or stopped.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
