Drug interactions
Clobazam + Olanzapine
Severity: Moderate
Clobazam and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so combined use can increase sedation, impaired coordination and respiratory depression. Benzodiazepines with olanzapine have also been associated with hypotension and excess sedation, particularly with parenteral olanzapine.
What this interaction means in plain words
Clobazam and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A enhancement and antipsychotic sedative effects.
What to do
Use the lowest effective doses and monitor sedation, blood pressure and respiratory status. Avoid giving intramuscular olanzapine close to parenteral benzodiazepines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Olanzapine?
MediHelp rates the interaction as moderate. Clobazam and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, so combined use can increase sedation, impaired coordination and respiratory depression. Benzodiazepines with olanzapine have also been associated with hypotension and excess sedation, particularly with parenteral olanzapine.
How serious is the interaction between Clobazam and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, blood pressure and respiratory status. Avoid giving intramuscular olanzapine close to parenteral benzodiazepines.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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