Drug interactions
Clobazam + Rabeprazole
Severity: Minor
Clobazam and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam's active metabolite N-desmethylclobazam is cleared by CYP2C19, which rabeprazole inhibits weakly. Exposure to the active metabolite may rise modestly, with possible added sedation.
What this interaction means in plain words
Clobazam and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP2C19 inhibition by rabeprazole reduces N-desmethylclobazam clearance.
What to do
Monitor for sedation or drowsiness and reduce the clobazam dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Rabeprazole?
MediHelp rates the interaction as minor. Clobazam and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam's active metabolite N-desmethylclobazam is cleared by CYP2C19, which rabeprazole inhibits weakly. Exposure to the active metabolite may rise modestly, with possible added sedation.
How serious is the interaction between Clobazam and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation or drowsiness and reduce the clobazam dose if these occur.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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