Drug interactions
Clobazam + Triprolidine
Severity: Moderate
Clobazam and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine, and a sedating antihistamine adds to its CNS depressant effects. This can cause pronounced drowsiness, impaired psychomotor performance and, in vulnerable patients, respiratory depression.
What this interaction means in plain words
Clobazam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 receptor blockade.
What to do
Counsel on sedation and avoid driving or hazardous tasks. Prefer a non-sedating antihistamine and monitor older or respiratory-compromised patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Triprolidine?
MediHelp rates the interaction as moderate. Clobazam and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine, and a sedating antihistamine adds to its CNS depressant effects. This can cause pronounced drowsiness, impaired psychomotor performance and, in vulnerable patients, respiratory depression.
How serious is the interaction between Clobazam and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid driving or hazardous tasks. Prefer a non-sedating antihistamine and monitor older or respiratory-compromised patients.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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