Drug interactions
Clobazam + Venlafaxine
Severity: Minor
Clobazam and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam, through its metabolite, is a weak CYP2D6 inhibitor and may modestly raise venlafaxine levels while lowering its active metabolite O-desmethylvenlafaxine. The overall change in activity is usually small. Additive sedation may also occur.
What this interaction means in plain words
Clobazam and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clobazam belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by clobazam reduces conversion of venlafaxine to O-desmethylvenlafaxine.
What to do
Monitor for venlafaxine adverse effects such as blood pressure elevation and nausea, and adjust the dose according to clinical response. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clobazam and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Venlafaxine?
MediHelp rates the interaction as minor. Clobazam and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clobazam, through its metabolite, is a weak CYP2D6 inhibitor and may modestly raise venlafaxine levels while lowering its active metabolite O-desmethylvenlafaxine. The overall change in activity is usually small. Additive sedation may also occur.
How serious is the interaction between Clobazam and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for venlafaxine adverse effects such as blood pressure elevation and nausea, and adjust the dose according to clinical response. No routine dose change is needed.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
