Drug interactions
Clobazam + Zaleplon
Severity: Moderate
Clobazam and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance GABA-A activity, so together they can increase sedation, psychomotor impairment and respiratory depression. Risk is higher in the elderly and with other CNS depressants.
What this interaction means in plain words
Clobazam and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Zaleplon belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor-mediated CNS depression.
What to do
Use the lowest effective zaleplon dose and avoid alcohol. Monitor for oversedation and reduce doses if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Zaleplon?
MediHelp rates the interaction as moderate. Clobazam and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance GABA-A activity, so together they can increase sedation, psychomotor impairment and respiratory depression. Risk is higher in the elderly and with other CNS depressants.
How serious is the interaction between Clobazam and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zaleplon dose and avoid alcohol. Monitor for oversedation and reduce doses if it occurs.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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