Drug interactions
Clofazimine + Fexinidazole
Severity: Major
Clofazimine and Fexinidazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval and its labeling advises against use with other QT-prolonging drugs. Clofazimine also prolongs QT, so the combination increases the risk of torsades de pointes.
What this interaction means in plain words
Clofazimine and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Avoid coadministration. If it cannot be avoided, obtain a baseline and follow-up ECG and correct potassium, magnesium and calcium before and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clofazimine
Frequently asked questions
Can I take Clofazimine with Fexinidazole?
MediHelp rates the interaction as major. Clofazimine and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval and its labeling advises against use with other QT-prolonging drugs. Clofazimine also prolongs QT, so the combination increases the risk of torsades de pointes.
How serious is the interaction between Clofazimine and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. If it cannot be avoided, obtain a baseline and follow-up ECG and correct potassium, magnesium and calcium before and during treatment.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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