Drug interactions
Clomipramine + Conivaptan
Severity: Moderate
Clomipramine and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a potent CYP3A4 inhibitor and may increase clomipramine concentrations, though CYP3A4 is only one of several pathways for clomipramine. Elevated levels could increase anticholinergic, sedative and cardiac effects.
What this interaction means in plain words
Clomipramine and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated clomipramine metabolism by conivaptan.
What to do
Monitor for tricyclic toxicity, including sedation, tachycardia and QT changes, during the short conivaptan course. Reduce the clomipramine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Conivaptan?
MediHelp rates the interaction as moderate. Clomipramine and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a potent CYP3A4 inhibitor and may increase clomipramine concentrations, though CYP3A4 is only one of several pathways for clomipramine. Elevated levels could increase anticholinergic, sedative and cardiac effects.
How serious is the interaction between Clomipramine and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity, including sedation, tachycardia and QT changes, during the short conivaptan course. Reduce the clomipramine dose if adverse effects appear.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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