Drug interactions
Clomipramine + Darifenacin
Severity: Moderate
Clomipramine and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a strongly anticholinergic tricyclic, and darifenacin is an antimuscarinic. Together they add to anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and confusion. Darifenacin is a CYP2D6 inhibitor and may also raise clomipramine exposure modestly.
What this interaction means in plain words
Clomipramine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Darifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects, plus darifenacin inhibition of CYP2D6 that reduces clomipramine metabolism.
What to do
Monitor for anticholinergic toxicity and signs of tricyclic excess such as sedation, tachycardia and arrhythmia. Reduce the clomipramine dose if adverse effects appear, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Darifenacin?
MediHelp rates the interaction as moderate. Clomipramine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a strongly anticholinergic tricyclic, and darifenacin is an antimuscarinic. Together they add to anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and confusion. Darifenacin is a CYP2D6 inhibitor and may also raise clomipramine exposure modestly.
How serious is the interaction between Clomipramine and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and signs of tricyclic excess such as sedation, tachycardia and arrhythmia. Reduce the clomipramine dose if adverse effects appear, especially in older patients.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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