Drug interactions
Clomipramine + Debrisoquine
Severity: Moderate
Clomipramine and Debrisoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Debrisoquine is an adrenergic neuron blocker that needs neuronal uptake to act. Tricyclic antidepressants block this uptake and can reduce its antihypertensive effect, leading to loss of blood pressure control.
What this interaction means in plain words
Clomipramine and Debrisoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clomipramine inhibits norepinephrine transporter uptake of debrisoquine into adrenergic neurons.
What to do
Monitor blood pressure and increase antihypertensive therapy or switch to another class if control is lost. Reassess when clomipramine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Debrisoquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Debrisoquine?
MediHelp rates the interaction as moderate. Clomipramine and Debrisoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Debrisoquine is an adrenergic neuron blocker that needs neuronal uptake to act. Tricyclic antidepressants block this uptake and can reduce its antihypertensive effect, leading to loss of blood pressure control.
How serious is the interaction between Clomipramine and Debrisoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase antihypertensive therapy or switch to another class if control is lost. Reassess when clomipramine is started or stopped.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
