Drug interactions
Clomipramine + Deferasirox
Severity: Moderate
Clomipramine and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2, which contributes to clomipramine metabolism, so clomipramine concentrations may rise. This can increase anticholinergic, cardiac and seizure risks.
What this interaction means in plain words
Clomipramine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Deferasirox belongs to Miscellaneous.
Why it happens
Inhibition of CYP1A2 by deferasirox reduces clomipramine clearance.
What to do
Monitor for tricyclic adverse effects and consider an ECG or plasma level check. Reduce the clomipramine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Clomipramine with Deferasirox?
MediHelp rates the interaction as moderate. Clomipramine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP1A2, which contributes to clomipramine metabolism, so clomipramine concentrations may rise. This can increase anticholinergic, cardiac and seizure risks.
How serious is the interaction between Clomipramine and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider an ECG or plasma level check. Reduce the clomipramine dose if toxicity appears.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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