Drug interactions
Clomipramine + Dextroamphetamine transdermal
Severity: Major
Clomipramine and Dextroamphetamine transdermal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics can potentiate amphetamines by increasing amphetamine availability at the site of action and amplifying noradrenergic effects. This can raise blood pressure and heart rate and cause arrhythmias. Clomipramine's serotonergic action also adds some serotonin syndrome risk.
What this interaction means in plain words
Clomipramine and Dextroamphetamine transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive adrenergic and serotonergic effects, with tricyclic-mediated potentiation of amphetamine action, and possible CYP2D6 interplay.
What to do
Monitor blood pressure, heart rate and ECG, and watch for signs of serotonin toxicity. Reduce the dose or choose an alternative if cardiovascular effects occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Dextroamphetamine transdermal?
MediHelp rates the interaction as major. Clomipramine and Dextroamphetamine transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics can potentiate amphetamines by increasing amphetamine availability at the site of action and amplifying noradrenergic effects. This can raise blood pressure and heart rate and cause arrhythmias. Clomipramine's serotonergic action also adds some serotonin syndrome risk.
How serious is the interaction between Clomipramine and Dextroamphetamine transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG, and watch for signs of serotonin toxicity. Reduce the dose or choose an alternative if cardiovascular effects occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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