Drug interactions
Clomipramine + Dextroamphetamine
Severity: Major
Clomipramine and Dextroamphetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics can potentiate the cardiovascular effects of amphetamines by blocking norepinephrine reuptake, and amphetamines may raise tricyclic levels. This may produce hypertension, tachycardia, arrhythmia and, with clomipramine, serotonin toxicity or seizures.
What this interaction means in plain words
Clomipramine and Dextroamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Additive noradrenergic and serotonergic effects, with possible CYP2D6-mediated increase in tricyclic levels.
What to do
Avoid combination if possible. If used, start with low doses and monitor blood pressure, heart rate, ECG and mental state.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Clomipramine with Dextroamphetamine?
MediHelp rates the interaction as major. Clomipramine and Dextroamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics can potentiate the cardiovascular effects of amphetamines by blocking norepinephrine reuptake, and amphetamines may raise tricyclic levels. This may produce hypertension, tachycardia, arrhythmia and, with clomipramine, serotonin toxicity or seizures.
How serious is the interaction between Clomipramine and Dextroamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination if possible. If used, start with low doses and monitor blood pressure, heart rate, ECG and mental state.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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