Drug interactions
Clomipramine + Dichlorphenamide
Severity: Moderate
Clomipramine and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide can cause hypokalemia and metabolic acidosis. Low potassium increases the risk of QT prolongation and arrhythmia in patients taking clomipramine, which has cardiac conduction effects.
What this interaction means in plain words
Clomipramine and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Carbonic anhydrase inhibition causes potassium loss, which potentiates tricyclic-related cardiac toxicity.
What to do
Monitor serum potassium and bicarbonate regularly and correct deficits. Consider an ECG if other QT-prolonging factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Clomipramine with Dichlorphenamide?
MediHelp rates the interaction as moderate. Clomipramine and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide can cause hypokalemia and metabolic acidosis. Low potassium increases the risk of QT prolongation and arrhythmia in patients taking clomipramine, which has cardiac conduction effects.
How serious is the interaction between Clomipramine and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and correct deficits. Consider an ECG if other QT-prolonging factors are present.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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