Drug interactions
Clomipramine + Diethylpropion
Severity: Major
Clomipramine and Diethylpropion: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic anorectic, and with clomipramine the cardiovascular response may be altered, with hypertension, tachycardia or arrhythmias. Combined CNS stimulation and lowered seizure threshold are also possible.
What this interaction means in plain words
Clomipramine and Diethylpropion can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Tricyclic blockade of noradrenaline reuptake and of uptake of indirect sympathomimetics alters the pressor response and adds to adrenergic stimulation.
What to do
Avoid combining where possible and choose a non-sympathomimetic weight-loss approach. If used together, monitor blood pressure and heart rhythm.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Diethylpropion, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Diethylpropion?
MediHelp rates the interaction as major. Clomipramine and Diethylpropion can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diethylpropion is a sympathomimetic anorectic, and with clomipramine the cardiovascular response may be altered, with hypertension, tachycardia or arrhythmias. Combined CNS stimulation and lowered seizure threshold are also possible.
How serious is the interaction between Clomipramine and Diethylpropion?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose a non-sympathomimetic weight-loss approach. If used together, monitor blood pressure and heart rhythm.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
