Drug interactions
Clomipramine + Difenoxin
Severity: Moderate
Clomipramine and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal metabolite with CNS activity, and combined use with a sedating tricyclic may increase drowsiness. Both drugs also have anticholinergic effects that may worsen constipation or ileus.
What this interaction means in plain words
Clomipramine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for sedation and signs of reduced bowel motility or abdominal distension. Use the lowest effective dose and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Difenoxin
Frequently asked questions
Can I take Clomipramine with Difenoxin?
MediHelp rates the interaction as moderate. Clomipramine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal metabolite with CNS activity, and combined use with a sedating tricyclic may increase drowsiness. Both drugs also have anticholinergic effects that may worsen constipation or ileus.
How serious is the interaction between Clomipramine and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and signs of reduced bowel motility or abdominal distension. Use the lowest effective dose and counsel on driving.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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