Drug interactions
Clomipramine + Dihydroergotamine intranasal
Severity: Moderate
Clomipramine and Dihydroergotamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity and the combination may increase the risk of serotonin syndrome. Intranasal dihydroergotamine is systemically absorbed, so the concern is similar to other routes though exposure is lower.
What this interaction means in plain words
Clomipramine and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity from serotonin reuptake inhibition and serotonin receptor agonism.
What to do
Monitor for signs of serotonin toxicity after dosing, and counsel the patient on symptoms. Choose a non-serotonergic migraine option if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Dihydroergotamine intranasal?
MediHelp rates the interaction as moderate. Clomipramine and Dihydroergotamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity and the combination may increase the risk of serotonin syndrome. Intranasal dihydroergotamine is systemically absorbed, so the concern is similar to other routes though exposure is lower.
How serious is the interaction between Clomipramine and Dihydroergotamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity after dosing, and counsel the patient on symptoms. Choose a non-serotonergic migraine option if symptoms occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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