Drug interactions
Clomipramine + Dopexamine
Severity: Moderate
Clomipramine and Dopexamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of catecholamine-type agents such as dopexamine. This may result in tachycardia, arrhythmias or blood pressure swings.
What this interaction means in plain words
Clomipramine and Dopexamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Clomipramine inhibits neuronal noradrenaline reuptake, which can enhance responses to adrenergic agents.
What to do
Monitor ECG and blood pressure continuously during dopexamine infusion and titrate the dose cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Dopexamine?
MediHelp rates the interaction as moderate. Clomipramine and Dopexamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of catecholamine-type agents such as dopexamine. This may result in tachycardia, arrhythmias or blood pressure swings.
How serious is the interaction between Clomipramine and Dopexamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and blood pressure continuously during dopexamine infusion and titrate the dose cautiously.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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