Drug interactions
Clomipramine + Echothiophate iodide
Severity: Minor
Clomipramine and Echothiophate iodide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Echothiophate is an ophthalmic cholinesterase inhibitor with limited systemic absorption, though it can inhibit cholinesterase systemically, while clomipramine is anticholinergic. The clinical effect of the combination is not well established.
What this interaction means in plain words
Clomipramine and Echothiophate iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing cholinergic and anticholinergic pharmacology; the clinical significance is not established.
What to do
No routine change is needed. Watch for reduced effect of either agent or cholinergic symptoms if systemic absorption is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Echothiophate iodide?
MediHelp rates the interaction as minor. Clomipramine and Echothiophate iodide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Echothiophate is an ophthalmic cholinesterase inhibitor with limited systemic absorption, though it can inhibit cholinesterase systemically, while clomipramine is anticholinergic. The clinical effect of the combination is not well established.
How serious is the interaction between Clomipramine and Echothiophate iodide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for reduced effect of either agent or cholinergic symptoms if systemic absorption is suspected.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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