Drug interactions
Clomipramine + Encorafenib
Severity: Major
Clomipramine and Encorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so together they raise the risk of torsades de pointes. Encorafenib can also induce CYP3A4, which may modestly alter clomipramine levels.
What this interaction means in plain words
Clomipramine and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Encorafenib belongs to Oncology.
Why it happens
Additive QT prolongation through ion channel effects.
What to do
Avoid if possible; otherwise obtain ECG and electrolytes at baseline and periodically. Interrupt or reduce encorafenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Encorafenib
Frequently asked questions
Can I take Clomipramine with Encorafenib?
MediHelp rates the interaction as major. Clomipramine and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so together they raise the risk of torsades de pointes. Encorafenib can also induce CYP3A4, which may modestly alter clomipramine levels.
How serious is the interaction between Clomipramine and Encorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain ECG and electrolytes at baseline and periodically. Interrupt or reduce encorafenib if QTc becomes markedly prolonged.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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