Drug interactions
Clomipramine + Estropipate
Severity: Minor
Clomipramine and Estropipate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may increase tricyclic antidepressant concentrations and adverse effects, while some reports describe a reduced antidepressant response. The interaction is inconsistent and usually of limited significance.
What this interaction means in plain words
Clomipramine and Estropipate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible estrogen-related inhibition of hepatic tricyclic metabolism; the mechanism is not well established.
What to do
Monitor antidepressant response and tricyclic adverse effects when estrogen therapy is started, changed or stopped. Adjust clomipramine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Estropipate?
MediHelp rates the interaction as minor. Clomipramine and Estropipate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may increase tricyclic antidepressant concentrations and adverse effects, while some reports describe a reduced antidepressant response. The interaction is inconsistent and usually of limited significance.
How serious is the interaction between Clomipramine and Estropipate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and tricyclic adverse effects when estrogen therapy is started, changed or stopped. Adjust clomipramine dose if needed.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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