Drug interactions
Clomipramine + Ethanol
Severity: Moderate
Clomipramine and Ethanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol enhances the sedative and psychomotor-impairing effects of clomipramine and may increase risk of hypotension and overdose toxicity. Heavy alcohol use also lowers the seizure threshold further.
What this interaction means in plain words
Clomipramine and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Advise patients to avoid alcohol during clomipramine treatment. Counsel about driving and machinery use if alcohol is consumed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Ethanol?
MediHelp rates the interaction as moderate. Clomipramine and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol enhances the sedative and psychomotor-impairing effects of clomipramine and may increase risk of hypotension and overdose toxicity. Heavy alcohol use also lowers the seizure threshold further.
How serious is the interaction between Clomipramine and Ethanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol during clomipramine treatment. Counsel about driving and machinery use if alcohol is consumed.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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