Drug interactions
Clomipramine + Fenbufen
Severity: Moderate
Clomipramine and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine impairs platelet serotonin uptake and fenbufen, an NSAID, inhibits platelet function and irritates the gastric mucosa. Together they raise the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Clomipramine and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation (serotonin reuptake inhibition plus cyclooxygenase inhibition) with NSAID-related mucosal injury.
What to do
Monitor for signs of GI bleeding and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Fenbufen?
MediHelp rates the interaction as moderate. Clomipramine and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine impairs platelet serotonin uptake and fenbufen, an NSAID, inhibits platelet function and irritates the gastric mucosa. Together they raise the risk of gastrointestinal and other bleeding.
How serious is the interaction between Clomipramine and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and use the lowest effective NSAID dose for the shortest time. Consider gastroprotection with a proton pump inhibitor in higher-risk patients.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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