Drug interactions
Clomipramine + Fenoprofen
Severity: Moderate
Clomipramine and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a strongly serotonergic tricyclic that inhibits platelet serotonin uptake, and fenoprofen adds antiplatelet and gastric-irritant effects. Together they increase the risk of bleeding, particularly upper gastrointestinal bleeding.
What this interaction means in plain words
Clomipramine and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive platelet dysfunction from serotonin reuptake inhibition and COX-1 inhibition, plus NSAID mucosal injury.
What to do
Monitor for bleeding and consider proton pump inhibitor gastroprotection in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Fenoprofen?
MediHelp rates the interaction as moderate. Clomipramine and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a strongly serotonergic tricyclic that inhibits platelet serotonin uptake, and fenoprofen adds antiplatelet and gastric-irritant effects. Together they increase the risk of bleeding, particularly upper gastrointestinal bleeding.
How serious is the interaction between Clomipramine and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider proton pump inhibitor gastroprotection in at-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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