Drug interactions
Clomipramine + Fentanyl transdermal
Severity: Major
Clomipramine and Fentanyl transdermal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with a sedating tricyclic increases CNS and respiratory depression. Clomipramine and fentanyl also both have serotonergic activity, so serotonin syndrome is possible.
What this interaction means in plain words
Clomipramine and Fentanyl transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, plus additive serotonergic effects.
What to do
Reserve for patients without adequate alternatives and monitor sedation, respiration and signs of serotonin toxicity. Reduce doses if excess sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Fentanyl transdermal?
MediHelp rates the interaction as major. Clomipramine and Fentanyl transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a sedating tricyclic increases CNS and respiratory depression. Clomipramine and fentanyl also both have serotonergic activity, so serotonin syndrome is possible.
How serious is the interaction between Clomipramine and Fentanyl transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for patients without adequate alternatives and monitor sedation, respiration and signs of serotonin toxicity. Reduce doses if excess sedation occurs.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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