Drug interactions
Clomipramine + Gabapentin
Severity: Moderate
Clomipramine and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and psychomotor impairment, and gabapentinoids can cause respiratory depression especially in older patients, those with lung disease, or when combined with other CNS depressants. Clomipramine also lowers the seizure threshold, which is relevant when gabapentin is used for epilepsy.
What this interaction means in plain words
Clomipramine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Gabapentin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Start with low doses and titrate slowly, and monitor for sedation, dizziness and respiratory depression. Warn the patient about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Gabapentin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Clomipramine with Gabapentin?
MediHelp rates the interaction as moderate. Clomipramine and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and psychomotor impairment, and gabapentinoids can cause respiratory depression especially in older patients, those with lung disease, or when combined with other CNS depressants. Clomipramine also lowers the seizure threshold, which is relevant when gabapentin is used for epilepsy.
How serious is the interaction between Clomipramine and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate slowly, and monitor for sedation, dizziness and respiratory depression. Warn the patient about driving and alcohol.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
