Drug interactions
Clomipramine + Glimepiride-pioglitazone
Severity: Minor
Clomipramine and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as clomipramine may alter glycemic control and blunt recognition of hypoglycemia. The effect on glimepiride and pioglitazone is usually small.
What this interaction means in plain words
Clomipramine and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Possible additive pharmacodynamic effect on glucose regulation; the mechanism is not well established.
What to do
Monitor blood glucose when clomipramine is started or stopped and adjust therapy only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Clomipramine and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as clomipramine may alter glycemic control and blunt recognition of hypoglycemia. The effect on glimepiride and pioglitazone is usually small.
How serious is the interaction between Clomipramine and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when clomipramine is started or stopped and adjust therapy only if control changes.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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