Drug interactions
Clomipramine + Glycopyrrolate inhaled
Severity: Minor
Clomipramine and Glycopyrrolate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled glycopyrrolate has low systemic exposure, but some drug is absorbed and clomipramine is strongly anticholinergic. Additive effects such as dry mouth, urinary retention and constipation are possible, especially in vulnerable patients.
What this interaction means in plain words
Clomipramine and Glycopyrrolate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic effects from low systemic exposure to glycopyrrolate and clomipramine.
What to do
Monitor for anticholinergic symptoms, particularly in patients with prostatic hypertrophy or narrow-angle glaucoma. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Glycopyrrolate inhaled?
MediHelp rates the interaction as minor. Clomipramine and Glycopyrrolate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inhaled glycopyrrolate has low systemic exposure, but some drug is absorbed and clomipramine is strongly anticholinergic. Additive effects such as dry mouth, urinary retention and constipation are possible, especially in vulnerable patients.
How serious is the interaction between Clomipramine and Glycopyrrolate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, particularly in patients with prostatic hypertrophy or narrow-angle glaucoma. No routine dose change is needed.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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