Drug interactions
Clomipramine + Glycopyrronium tosylate
Severity: Moderate
Clomipramine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate is absorbed systemically to a small degree and can cause anticholinergic effects. Combined with clomipramine, this may add to dry mouth, blurred vision, urinary retention and constipation.
What this interaction means in plain words
Clomipramine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects from systemically absorbed glycopyrronium and clomipramine.
What to do
Monitor for anticholinergic effects and counsel patients to report urinary hesitancy or visual changes. Stop the topical product if significant effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Clomipramine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium tosylate is absorbed systemically to a small degree and can cause anticholinergic effects. Combined with clomipramine, this may add to dry mouth, blurred vision, urinary retention and constipation.
How serious is the interaction between Clomipramine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and counsel patients to report urinary hesitancy or visual changes. Stop the topical product if significant effects occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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