Drug interactions
Clomipramine + Homatropine
Severity: Moderate
Clomipramine and Homatropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Homatropine is an antimuscarinic and clomipramine has marked anticholinergic activity. Together they can cause additive dry mouth, constipation, urinary retention, blurred vision and confusion.
What this interaction means in plain words
Clomipramine and Homatropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Homatropine belongs to Genitourinary.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for anticholinergic effects and reduce the dose of one drug or use an alternative if symptoms occur. Take extra care in older patients and in those with glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Homatropine
- Amantadine + Homatropine Moderate
- Amitriptyline + Homatropine Moderate
- Atropine + Homatropine Moderate
- Benztropine + Homatropine Moderate
- Bethanechol + Homatropine Moderate
- Chlorpromazine + Homatropine Moderate
Frequently asked questions
Can I take Clomipramine with Homatropine?
MediHelp rates the interaction as moderate. Clomipramine and Homatropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Homatropine is an antimuscarinic and clomipramine has marked anticholinergic activity. Together they can cause additive dry mouth, constipation, urinary retention, blurred vision and confusion.
How serious is the interaction between Clomipramine and Homatropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and reduce the dose of one drug or use an alternative if symptoms occur. Take extra care in older patients and in those with glaucoma or urinary obstruction.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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